Biography

I joined Tsinghua University as a tenure-track assistant professor and principal investigator in biomedical AI. Previously, I served as the founding member and head of AI systems at a2z Radiology AI, and as a postdoctoral fellow at Harvard University with Professor Pranav Rajpurkar. I obtained my Ph.D. in Computer Science from the University of Hong Kong, advised by Professor Yizhou Yu. I spent two years at Tencent as a research scientist, and received degrees from Nanjing University and Wuhan University.

Research

Our lab, AIMS (AI for Medicine at Scale), develops scalable, trustworthy, and medically useful AI. We are particularly interested in curating patient–AI ecosystems — embodied intelligent agents that improve healthcare delivery through direct patient–AI interactions.

We are actively recruiting self-motivated researchers at all levels: Postdocs, Ph.D. students, Undergraduates, Visiting scholars, and Research Interns at Tsinghua. We especially welcome candidates with clinical medical backgrounds or wearable device development experience. Please email your CV directly.

Recent News

Jul 2025
Paper on benchmarking retinal anomaly detection (BenchReAD) accepted at MICCAI 2025. Congrats Chenyu!
Jun 2025
Paper on efficient medical vision-language alignment published in IEEE Transactions on Medical Imaging. Congrats Chenyu!
May 2025
Review on "Multimodal generative AI for interpreting 3D medical images and videos" published in npj Digital Medicine. Congrats Jung-Oh!
Apr 2025
Paper on multimodal generative medical AI published in Cell Reports Medicine. Congrats Fei! Also, paper on dynamic neural networks in IEEE TNNLS. Congrats Meng!
Mar 2025
Paper on MedTrinity-25M, a large-scale multimodal medical dataset, accepted at ICLR 2025. Congrats Yunfei!
Feb 2025
Paper on predicting therapy response for breast cancer published in IEEE JBHI. Congrats Yuan!
Jan 2025
Two papers in Nature Medicine: one on self-improving medical foundation models, one on evaluating LLMs for patient interaction. Congrats Jinzhuo & Shreya!

Honors & Awards

Lab Members

Research Students & Staff (Tsinghua)

Bohan Xia 2026–Present · PhD @ THU
Mingrui Shao 2026–Present · MS @ THU

Co-advised Members

Linwei Chen 2025–Present · Postdoc @ HKGAI
Chenyu Lian 2024–Present · PhD @ HKPU
ICLR'23 TMI'25 MICCAI'25
Shuai Wu 2025–Present · PhD @ HKU
Jie Lin 2025–Present · PhD @ Xiamen University

Alumni

Hao Yang PhD @ CAS
Nat. Biomed. Eng.'26
Yuan Gao PhD @ Netherlands Cancer Institute
Nat. Commun.'24 MICCAI'24 JBHI'25
Xing Wang PhD @ Netherlands Cancer Institute
Nat. Commun.'25
Weijian Huang PhD @ CAS
Nat. Commun.'24
Chixiang Lu Past: UG @ HUST · Now: PhD @ HKU
ICCV'21 IPMI'21 TMI'22 TPAMI'23
Meng Lou Past: Deepwise · Now: PhD @ HKU
TNNLS'25 Neural Netw.'25
Jiarun Liu PhD @ CAS
MICCAI'24 TMI'25
Yunxiang Fu Past: UG @ HKU · Now: PhD @ HKU
ICLR'23
Jiaxin Wu Past: UG @ HKU · Now: Software Engineer @ UBS
Zixuan Shan Past: UG @ HKU · Now: MS @ NYU

Publications

Full list on Google Scholar (incl. preprints)
2025
An evaluation framework for clinical use of large language models in patient interaction tasks
Shreya Johri, Jaehwan Jeong, Benjamin A Tran, Daniel I Schlessinger, Shannon Wongvibulsin, Leandra A Barnes, Hong-Yu Zhou, Zhuo Ran Cai, Eliezer M Van Allen, David Kim, Roxana Daneshjou, Pranav Rajpurkar
Nature Medicine, 2025
Self-improving generative foundation model for synthetic medical image generation and clinical applications
Jinzhuo Wang, Kai Wang, Yunfang Yu, Yuxing Lu, ..., Hong-Yu Zhou, ..., Kang Zhang, Jia Qu
Nature Medicine, 2025
MetaGP: A Generative Foundation Model Integrating Electronic Health Records and Multimodal Imaging for Addressing Unmet Clinical Needs
Fei Liu, Hong-Yu Zhou, Kai Wang, Yunfang Yu, ..., Kang Zhang
Cell Reports Medicine, 2025
Multimodal Generative AI for Interpreting 3D Medical Images and Videos
Jung-Oh Lee, Hong-Yu Zhou, Tyler M Berzin, Daniel K Sodickson, Pranav Rajpurkar
npj Digital Medicine, 2025
BenchReAD: A Systematic Benchmark for Retinal Anomaly Detection
Chenyu Lian, Hong-Yu Zhou, Zhanli Hu, Jing Qin
MICCAI, 2025
Efficient Medical Vision-Language Alignment Through Adapting Masked Vision Models
Chenyu Lian, Hong-Yu Zhou, Dongyun Liang, Jing Qin, Liansheng Wang
IEEE Transactions on Medical Imaging, 2025
Multi-Modal Longitudinal Representation Learning for Predicting Neoadjuvant Therapy Response in Breast Cancer Treatment
Yuan Gao, Tao Tan, Xin Wang, Regina Beets-Tan, Tianyu Zhang, ..., Hong-Yu Zhou, Ritse Mann
IEEE Journal of Biomedical and Health Informatics, 2025
TransXNet: Learning Both Global and Local Dynamics with a Dual Dynamic Token Mixer for Visual Recognition
Meng Lou, Shu Zhang, Hong-Yu Zhou, Sibei Yang, Chuan Wu, Yizhou Yu
IEEE Transactions on Neural Networks and Learning Systems, 2025
SDR-Former: A Siamese Dual-Resolution Transformer for Liver Lesion Classification Using 3D Multi-Phase Imaging
Meng Lou, Hanning Ying, Xiaoqing Liu, Hong-Yu Zhou, Yuqin Zhang, Yizhou Yu
Neural Networks, 2025
MedTrinity-25M: A Large-Scale Multimodal Dataset with Multigranular Annotations for Medicine
Yunfei Xie, Ce Zhou, Lang Gao, ..., Hong-Yu Zhou, ..., Cihang Xie, Yuyin Zhou
ICLR, 2025
2024
Enhancing Representation in Radiography-Reports Foundation Model: A Granular Alignment Algorithm Using Masked Contrastive Learning
Weijian Huang, Cheng Li, Hong-Yu Zhou, Hao Yang, Jiarun Liu, Yong Liang, Hairong Zheng, Shaoting Zhang, Shanshan Wang
Nature Communications, 2024
An Explainable Longitudinal Multi-Modal Fusion Model for Predicting Neoadjuvant Therapy Response in Women with Breast Cancer
Yuan Gao, ..., Hong-Yu Zhou, ..., Tao Tan, Ritse Mann
Nature Communications, 2024
Concepts and Applications of Digital Twins in Healthcare and Medicine
Kang Zhang, Hong-Yu Zhou, Daniel T Baptista-Hon, ..., Joseph Wu
Patterns, 2024
A Survey on Graph Neural Networks and Graph Transformers in Computer Vision: A Task-Oriented Perspective
Chaoqi Chen, Yushuang Wu, Qiyuan Dai, Hong-Yu Zhou, Mutian Xu, Sibei Yang, Xiaoguang Han, Yizhou Yu
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2024
Swin-UMamba†: Adapting Mamba-Based Vision Foundation Models for Medical Image Segmentation
Jiarun Liu, Hao Yang, Hong-Yu Zhou, Lequan Yu, Yong Liang, Yizhou Yu, Shaoting Zhang, Hairong Zheng, Shanshan Wang
IEEE Transactions on Medical Imaging, 2024
Swin-UMamba: Mamba-Based UNet with ImageNet-Based Pretraining
Jiarun Liu, Hao Yang, Hong-Yu Zhou, et al.
MICCAI, 2024
Cross-Dimensional Medical Self-Supervised Representation Learning Based on a Pseudo-3D Transformation
Fei Gao, Siwen Wang, Churan Wang, Fandong Zhang, Hong-Yu Zhou, Yizhou Wang, Gang Yu, Yizhou Yu
MICCAI, 2024
Improving Neoadjuvant Therapy Response Prediction by Integrating Longitudinal Mammogram Generation with Cross-Modal Radiological Reports
Yuan Gao, Hong-Yu Zhou, Xin Wang, et al.
MICCAI, 2024
2023
A Transformer-Based Representation-Learning Model with Unified Processing of Multimodal Input for Clinical Diagnostics
Hong-Yu Zhou, Yizhou Yu, Chengdi Wang, Shu Zhang, Yuanxu Gao, Jia Pan, Jun Shao, Guangming Lu, Kang Zhang, Weimin Li
Nature Biomedical Engineering, 2023
A Unified Visual Information Preservation Framework for Self-Supervised Pre-Training in Medical Image Analysis
Hong-Yu Zhou, Chixiang Lu, Chaoqi Chen, Sibei Yang, Yizhou Yu
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2023
nnFormer: Volumetric Medical Image Segmentation via a 3D Transformer
Hong-Yu Zhou, Jiansen Guo, Yinghao Zhang, Xiaoguang Han, Lequan Yu, Liansheng Wang, Yizhou Yu
IEEE Transactions on Image Processing, 2023
Protein Representation Learning via Knowledge Enhanced Primary Structure Modeling
Hong-Yu Zhou, Yunxiang Fu, Zhicheng Bian, Cheng Bian, Yizhou Yu
ICLR, 2023
Advancing Radiograph Representation Learning with Masked Record Modeling
Hong-Yu Zhou, Chenyu Lian, Liansheng Wang, Yizhou Yu
ICLR, 2023
Activate and Reject: Towards Safe Domain Generalization Under Category Shift
Chaoqi Chen, Luyao Tang, Leitian Tao, Hong-Yu Zhou, Yue Huang, Xiaoguang Han, Yizhou Yu
ICCV, 2023
DDCoT: Duty-Distinct Chain-of-Thought Prompting for Multimodal Reasoning in Language Models
Ge Zheng, Bin Yang, Jiajin Tang, Hong-Yu Zhou, Sibei Yang
NeurIPS, 2023
2022
Generalized Radiograph Representation Learning via Cross-Supervision Between Images and Free-Text Radiology Reports
Hong-Yu Zhou, Xiaoyu Chen, Yinghao Zhang, Ruibang Luo, Liansheng Wang, Yizhou Yu
Nature Machine Intelligence, 2022
GraVIS: Grouping Augmented Views From Independent Sources for Dermatology Analysis
Hong-Yu Zhou, Chixiang Lu, Liansheng Wang, Yizhou Yu
IEEE Transactions on Medical Imaging, 2022
MASS: Modality-Collaborative Semi-Supervised Segmentation by Exploiting Cross-Modal Consistency from Unpaired CT and MRI Images
Xiaoyu Chen, Hong-Yu Zhou, Feng Liu, Jiansen Guo, Liansheng Wang, Yizhou Yu
Medical Image Analysis, 2022
Relation Matters: Foreground-Aware Graph-Based Relational Reasoning for Domain Adaptive Object Detection
Chaoqi Chen, Jiongcheng Li, Hong-Yu Zhou, Xiaoguang Han, Yue Huang, Xinghao Ding, Yizhou Yu
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2022
Development and Validation of an Abnormality-Derived Deep-Learning Diagnostic System for Major Respiratory Diseases
Chengdi Wang, Jiechao Ma, Shu Zhang, ..., Hong-Yu Zhou, ..., Weimin Li
npj Digital Medicine, 2022
2021
Preservational Learning Improves Self-Supervised Medical Image Models by Reconstructing Diverse Contexts
Hong-Yu Zhou, Chixiang Lu, Sibei Yang, Xiaoguang Han, Yizhou Yu
ICCV, 2021
SSMD: Semi-Supervised Medical Image Detection with Adaptive Consistency and Heterogeneous Perturbation
Hong-Yu Zhou, Chengdi Wang, Haofeng Li, Gang Wang, Shu Zhang, Weimin Li, Yizhou Yu
Medical Image Analysis, 2021
ConvNets vs. Transformers: Whose Visual Representations Are More Transferable?
Hong-Yu Zhou, Chixiang Lu, Sibei Yang, Yizhou Yu
ICCV, 2021
Generalized Organ Segmentation by Imitating One-Shot Reasoning Using Anatomical Correlation
Hong-Yu Zhou, Hualuo Liu, Shilei Cao, Dong Wei, Chixiang Lu, Yizhou Yu, Kai Ma, Yefeng Zheng
IPMI, 2021
2020
Comparing to Learn: Surpassing ImageNet Pretraining on Radiographs by Comparing Image Representations
Hong-Yu Zhou, Shuang Yu, Cheng Bian, Yifan Hu, Kai Ma, Yefeng Zheng
MICCAI, 2020
Difficulty-Aware Glaucoma Classification with Multi-Rater Consensus Modeling
Shuang Yu, Hong-Yu Zhou, Kai Ma, Cheng Bian, Chunyan Chu, Hanruo Liu, Yefeng Zheng
MICCAI, 2020
2018
ThiNet: Pruning CNN Filters for a Thinner Net
Jian-Hao Luo, Hao Zhang, Hong-Yu Zhou, Chen-Wei Xie, Jianxin Wu, Weiyao Lin
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2018
Age Estimation Using Expectation of Label Distribution Learning
Bin-Bin Gao, Hong-Yu Zhou, Jianxin Wu, Xin Geng
IJCAI, 2018
2017
Adaptive Feeding: Achieving Fast and Accurate Detections by Adaptively Combining Object Detectors
Hong-Yu Zhou, Bin-Bin Gao, Jianxin Wu
ICCV, 2017